CACNA1I-FBXW5 Fusion FISH Probe
The CACNA1I-FBXW5 Fusion FISH Probe is used to confirm a fusion of the CACNA1I and FBXW5 genes. The fusion of the CACNA1I and FBXW5 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CACNA1I-FBXW5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-RERE | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-REOR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-REGO | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-REGR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-REAQ | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-ORRE | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-OROR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-ORGO | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GORE | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GOOR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GOGO | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GOGR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GRRE | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GROR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GRGO | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GRGR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-AQRE | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-AQOR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-AQGO | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-AQGR | 20 (40 μL) | 200 μL |
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| CACNA1I-FBXW5-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1I Gene Summary
This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 I
Chromosome: CHR22: 39966757 -40085740
Locus: 22q13.1
FBXW5 Gene Summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Gene Name: F-box And WD Repeat Domain Containing 5
Chromosome: CHR9: 139834886 -139839173
Locus: 9q34.3
Gene Diseases
The CACNA1I FBXW5 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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