CADM2-FHIT Fusion FISH Probe
The CADM2-FHIT Fusion FISH Probe is used to confirm a fusion of the CADM2 and FHIT genes. The fusion of the CADM2 and FHIT genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CADM2-FHIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-RERE | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-REOR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-REGO | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-REGR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-REAQ | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-ORRE | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-OROR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-ORGO | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GORE | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GOOR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GOGO | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GOGR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GRRE | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GROR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GRGO | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GRGR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-AQRE | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-AQOR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-AQGO | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-AQGR | 20 (40 μL) | 200 μL |
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| CADM2-FHIT-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
CADM2 Gene Summary
This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Cell Adhesion Molecule 2
Chromosome: CHR3: 85008132 -86123579
Locus: 3p12.1
Gene Diseases
The CADM2 FHIT Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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