CADPS-FHIT Fusion FISH Probe
The CADPS-FHIT Fusion FISH Probe is used to confirm a fusion of the CADPS and FHIT genes. The fusion of the CADPS and FHIT genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CADPS-FHIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-RERE | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-REOR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-REGO | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-REGR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-REAQ | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-ORRE | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-OROR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-ORGO | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GORE | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GOOR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GOGO | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GOGR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GRRE | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GROR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GRGO | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GRGR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-AQRE | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-AQOR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-AQGO | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-AQGR | 20 (40 μL) | 200 μL |
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| CADPS-FHIT-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
CADPS Gene Summary
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Gene Name: Calcium Dependent Secretion Activator
Chromosome: CHR3: 62384020 -62861064
Locus: 3p14.2
Gene Diseases
The CADPS FHIT Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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