CADPS2-DHCR7 Fusion FISH Probe
The CADPS2-DHCR7 Fusion FISH Probe is used to confirm a fusion of the CADPS2 and DHCR7 genes. The fusion of the CADPS2 and DHCR7 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CADPS2-DHCR7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-RERE | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-REOR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-REGO | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-REGR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-REAQ | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-ORRE | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-OROR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-ORGO | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-ORAQ | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GORE | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GOOR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GOGO | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GOGR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GOAQ | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GRRE | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GROR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GRGO | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GRGR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-GRAQ | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-AQRE | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-AQOR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-AQGO | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-AQGR | 20 (40 μL) | 200 μL |
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| CADPS2-DHCR7-20-AQAQ | 20 (40 μL) | 200 μL |
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DHCR7 Gene Summary
This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009]
Gene Name: 7-dehydrocholesterol Reductase
Chromosome: CHR11: 71145456 -71159477
Locus: 11q13.4
CADPS2 Gene Summary
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Name: Calcium Dependent Secretion Activator 2
Chromosome: CHR7: 121958477 -122526813
Locus: 7q31.32
Gene Diseases
The CADPS2 DHCR7 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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