CALD1-AKR1B10 Fusion FISH Probe
The CALD1-AKR1B10 Fusion FISH Probe is used to confirm a fusion of the CALD1 and AKR1B10 genes. The fusion of the CALD1 and AKR1B10 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CALD1-AKR1B10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-RERE | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-REOR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-REGO | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-REGR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-REAQ | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-ORRE | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-OROR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-ORGO | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-ORAQ | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GORE | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GOOR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GOGO | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GOGR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GOAQ | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GRRE | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GROR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GRGO | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GRGR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-GRAQ | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-AQRE | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-AQOR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-AQGO | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-AQGR | 20 (40 μL) | 200 μL |
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| CALD1-AKR1B10-20-AQAQ | 20 (40 μL) | 200 μL |
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CALD1 Gene Summary
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Caldesmon 1
Chromosome: CHR7: 134464163 -134655480
Locus: 7q33
AKR1B10 Gene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Gene Name: Aldo-keto Reductase Family 1 Member B10
Chromosome: CHR7: 134212343 -134226166
Locus: 7q33
Gene Diseases
The CALD1 AKR1B10 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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