CALD1-EXOC4 Fusion FISH Probe
The CALD1-EXOC4 Fusion FISH Probe is used to confirm a fusion of the CALD1 and EXOC4 genes. The fusion of the CALD1 and EXOC4 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CALD1-EXOC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-RERE | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-REOR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-REGO | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-REGR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-REAQ | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-ORRE | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-OROR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-ORGO | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GORE | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GOOR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GOGO | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GOGR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GRRE | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GROR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GRGO | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GRGR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-AQRE | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-AQOR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-AQGO | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-AQGR | 20 (40 μL) | 200 μL |
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| CALD1-EXOC4-20-AQAQ | 20 (40 μL) | 200 μL |
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CALD1 Gene Summary
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Caldesmon 1
Chromosome: CHR7: 134464163 -134655480
Locus: 7q33
EXOC4 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 4
Chromosome: CHR7: 132937822 -133750513
Locus: 7q33
Gene Diseases
The CALD1 EXOC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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