CALR-TNNT1 Fusion FISH Probe
The CALR-TNNT1 Fusion FISH Probe is used to confirm a fusion of the CALR and TNNT1 genes. The fusion of the CALR and TNNT1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CALR-TNNT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-RERE | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-REOR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-REGO | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-REGR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-REAQ | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-ORRE | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-OROR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-ORGO | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GORE | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GOOR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GOGO | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GOGR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GRRE | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GROR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GRGO | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GRGR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-AQRE | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-AQOR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-AQGO | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-AQGR | 20 (40 μL) | 200 μL |
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| CALR-TNNT1-20-AQAQ | 20 (40 μL) | 200 μL |
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CALR Gene Summary
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
Gene Name: Calreticulin
Chromosome: CHR19: 13049413 -13055304
Locus: 19p13.13
TNNT1 Gene Summary
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Troponin T1, Slow Skeletal Type
Chromosome: CHR19: 55644160 -55660606
Locus: 19q13.42
Gene Diseases
The CALR TNNT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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