CALR3-PLCB1 Fusion FISH Probe
The CALR3-PLCB1 Fusion FISH Probe is used to confirm a fusion of the CALR3 and PLCB1 genes. The fusion of the CALR3 and PLCB1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CALR3-PLCB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-RERE | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-REOR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-REGO | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-REGR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-REAQ | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-ORRE | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-OROR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-ORGO | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GORE | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GOOR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GOGO | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GOGR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GRRE | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GROR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GRGO | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GRGR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-AQRE | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-AQOR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-AQGO | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-AQGR | 20 (40 μL) | 200 μL |
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| CALR3-PLCB1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLCB1 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phospholipase C Beta 1
Chromosome: CHR20: 8113295 -8865547
Locus: 20p12.3
CALR3 Gene Summary
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
Gene Name: Calreticulin 3
Chromosome: CHR19: 16589874 -16607003
Locus: 19p13.11
Gene Diseases
The CALR3 PLCB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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