CAPNS1-MTA2 Fusion FISH Probe
The CAPNS1-MTA2 Fusion FISH Probe is used to confirm a fusion of the CAPNS1 and MTA2 genes. The fusion of the CAPNS1 and MTA2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAPNS1-MTA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-RERE | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-REOR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-REGO | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-REGR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-REAQ | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-ORRE | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-OROR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-ORGO | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GORE | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GOOR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GOGO | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GOGR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GRRE | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GROR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GRGO | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GRGR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-AQRE | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-AQOR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-AQGO | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-AQGR | 20 (40 μL) | 200 μL |
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| CAPNS1-MTA2-20-AQAQ | 20 (40 μL) | 200 μL |
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CAPNS1 Gene Summary
This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Gene Name: Calpain Small Subunit 1
Chromosome: CHR19: 36630917 -36641255
Locus: 19q13.12
MTA2 Gene Summary
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
Gene Name: Metastasis Associated 1 Family Member 2
Chromosome: CHR11: 62360674 -62369312
Locus: 11q12.3
Gene Diseases
The CAPNS1 MTA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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