CAPZA2-ABCB1 Fusion FISH Probe
The CAPZA2-ABCB1 Fusion FISH Probe is used to confirm a fusion of the CAPZA2 and ABCB1 genes. The fusion of the CAPZA2 and ABCB1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAPZA2-ABCB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-RERE | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-REOR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-REGO | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-REGR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-REAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-ORRE | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-OROR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-ORGO | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GORE | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GOOR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GOGO | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GOGR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GRRE | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GROR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GRGO | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GRGR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-AQRE | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-AQOR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-AQGO | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-AQGR | 20 (40 μL) | 200 μL |
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| CAPZA2-ABCB1-20-AQAQ | 20 (40 μL) | 200 μL |
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CAPZA2 Gene Summary
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
Gene Name: Capping Actin Protein Of Muscle Z-line Alpha Subunit 2
Chromosome: CHR7: 116502562 -116559313
Locus: 7q31.2
ABCB1 Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Name: ATP Binding Cassette Subfamily B Member 1
Chromosome: CHR7: 87133178 -87342639
Locus: 7q21.12
Gene Diseases
The CAPZA2 ABCB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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