CAPZA2-MET Fusion FISH Probe
The CAPZA2-MET Fusion FISH Probe is used to confirm a fusion of the CAPZA2 and MET genes. The fusion of the CAPZA2 and MET genes has been associated with Lung Adenocarcinoma, Breast Invasive Carcinoma, and Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAPZA2-MET-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-RERE | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-REOR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-REGO | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-REGR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-REAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-ORRE | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-OROR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-ORGO | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GORE | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GOOR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GOGO | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GOGR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GRRE | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GROR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GRGO | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GRGR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-AQRE | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-AQOR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-AQGO | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-AQGR | 20 (40 μL) | 200 μL |
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| CAPZA2-MET-20-AQAQ | 20 (40 μL) | 200 μL |
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CAPZA2 Gene Summary
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
Gene Name: Capping Actin Protein Of Muscle Z-line Alpha Subunit 2
Chromosome: CHR7: 116502562 -116559313
Locus: 7q31.2
MET Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Gene Name: MET Proto-oncogene, Receptor Tyrosine Kinase
Chromosome: CHR7: 116312458 -116438440
Locus: 7q31.2
Gene Diseases
The CAPZA2 MET Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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