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CAPZB-CFL1 Fusion FISH Probe

The CAPZB-CFL1 Fusion FISH Probe is used to confirm a fusion of the CAPZB and CFL1 genes. The fusion of the CAPZB and CFL1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CAPZB-CFL1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CAPZB-CFL1-20-RERE 20 (40 μL) 200 μL
CAPZB-CFL1-20-REOR 20 (40 μL) 200 μL
CAPZB-CFL1-20-REGO 20 (40 μL) 200 μL
CAPZB-CFL1-20-REGR 20 (40 μL) 200 μL
CAPZB-CFL1-20-REAQ 20 (40 μL) 200 μL
CAPZB-CFL1-20-ORRE 20 (40 μL) 200 μL
CAPZB-CFL1-20-OROR 20 (40 μL) 200 μL
CAPZB-CFL1-20-ORGO 20 (40 μL) 200 μL
CAPZB-CFL1-20-ORAQ 20 (40 μL) 200 μL
CAPZB-CFL1-20-GORE 20 (40 μL) 200 μL
CAPZB-CFL1-20-GOOR 20 (40 μL) 200 μL
CAPZB-CFL1-20-GOGO 20 (40 μL) 200 μL
CAPZB-CFL1-20-GOGR 20 (40 μL) 200 μL
CAPZB-CFL1-20-GOAQ 20 (40 μL) 200 μL
CAPZB-CFL1-20-GRRE 20 (40 μL) 200 μL
CAPZB-CFL1-20-GROR 20 (40 μL) 200 μL
CAPZB-CFL1-20-GRGO 20 (40 μL) 200 μL
CAPZB-CFL1-20-GRGR 20 (40 μL) 200 μL
CAPZB-CFL1-20-GRAQ 20 (40 μL) 200 μL
CAPZB-CFL1-20-AQRE 20 (40 μL) 200 μL
CAPZB-CFL1-20-AQOR 20 (40 μL) 200 μL
CAPZB-CFL1-20-AQGO 20 (40 μL) 200 μL
CAPZB-CFL1-20-AQGR 20 (40 μL) 200 μL
CAPZB-CFL1-20-AQAQ 20 (40 μL) 200 μL

CAPZB Gene Summary

This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

Gene Name: Capping Actin Protein Of Muscle Z-line Beta Subunit

Chromosome: CHR1: 19665266 -19812066

Locus: 1p36.13

CFL1 Gene Summary

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Gene Name: Cofilin 1

Chromosome: CHR11: 65622284 -65625804

Locus: 11q13.1

Gene Diseases

The CAPZB CFL1 Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.