CARD8-BCKDHA Fusion FISH Probe
The CARD8-BCKDHA Fusion FISH Probe is used to confirm a fusion of the CARD8 and BCKDHA genes. The fusion of the CARD8 and BCKDHA genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CARD8-BCKDHA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-RERE | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-REOR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-REGO | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-REGR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-REAQ | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-ORRE | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-OROR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-ORGO | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-ORAQ | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GORE | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GOOR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GOGO | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GOGR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GOAQ | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GRRE | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GROR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GRGO | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GRGR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-GRAQ | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-AQRE | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-AQOR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-AQGO | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-AQGR | 20 (40 μL) | 200 μL |
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| CARD8-BCKDHA-20-AQAQ | 20 (40 μL) | 200 μL |
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BCKDHA Gene Summary
The branched-chain alpha-keto acid (BCAA) dehydrogenase (BCKD) complex is an innter mitochondrial enzyme complex that catalyzes the second major step in the catabolism of the branched-chain amino acids leucine, isoleucine, and valine. The BCKD complex consists of three catalytic components: a heterotetrameric (alpha2-beta2) branched-chain alpha-keto acid decarboxylase (E1), a dihydrolipoyl transacylase (E2), and a dihydrolipoamide dehydrogenase (E3). This gene encodes the alpha subunit of the decarboxylase (E1) component. Mutations in this gene result in maple syrup urine disease, type IA. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Name: Branched Chain Keto Acid Dehydrogenase E1, Alpha Polypeptide
Chromosome: CHR19: 41903693 -41930910
Locus: 19q13.2
CARD8 Gene Summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Gene Name: Caspase Recruitment Domain Family Member 8
Chromosome: CHR19: 48711342 -48759203
Locus: 19q13.33
Gene Diseases
The CARD8 BCKDHA Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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