CASC3-SIPA1L3 Fusion FISH Probe
The CASC3-SIPA1L3 Fusion FISH Probe is used to confirm a fusion of the CASC3 and SIPA1L3 genes. The fusion of the CASC3 and SIPA1L3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CASC3-SIPA1L3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-RERE | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-REOR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-REGO | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-REGR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-REAQ | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-ORRE | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-OROR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-ORGO | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GORE | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GOOR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GOGO | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GOGR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GRRE | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GROR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GRGO | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GRGR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-AQRE | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-AQOR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-AQGO | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-AQGR | 20 (40 μL) | 200 μL |
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| CASC3-SIPA1L3-20-AQAQ | 20 (40 μL) | 200 μL |
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CASC3 Gene Summary
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]
Gene Name: Cancer Susceptibility 3
Chromosome: CHR17: 38296506 -38328431
Locus: 17q21.1
SIPA1L3 Gene Summary
This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016]
Gene Name: Signal Induced Proliferation Associated 1 Like 3
Chromosome: CHR19: 38397867 -38699008
Locus: 19q13.13-q13.2
Gene Diseases
The CASC3 SIPA1L3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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