CASC4-TGM5 Fusion FISH Probe
The CASC4-TGM5 Fusion FISH Probe is used to confirm a fusion of the CASC4 and TGM5 genes. The fusion of the CASC4 and TGM5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CASC4-TGM5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-RERE | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-REOR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-REGO | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-REGR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-REAQ | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-ORRE | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-OROR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-ORGO | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GORE | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GOOR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GOGO | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GOGR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GRRE | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GROR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GRGO | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GRGR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-AQRE | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-AQOR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-AQGO | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-AQGR | 20 (40 μL) | 200 μL |
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| CASC4-TGM5-20-AQAQ | 20 (40 μL) | 200 μL |
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TGM5 Gene Summary
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]
Gene Name: Transglutaminase 5
Chromosome: CHR15: 43524792 -43559055
Locus: 15q15.2
CASC4 Gene Summary
The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Gene Name: Cancer Susceptibility 4
Chromosome: CHR15: 44580908 -44707959
Locus: 15q15.3
Gene Diseases
The CASC4 TGM5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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