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CASP8-CFLAR Fusion FISH Probe

The CASP8-CFLAR Fusion FISH Probe is used to confirm a fusion of the CASP8 and CFLAR genes. The fusion of the CASP8 and CFLAR genes has been associated with Stomach Adenocarcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CASP8-CFLAR-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CASP8-CFLAR-20-RERE 20 (40 μL) 200 μL
CASP8-CFLAR-20-REOR 20 (40 μL) 200 μL
CASP8-CFLAR-20-REGO 20 (40 μL) 200 μL
CASP8-CFLAR-20-REGR 20 (40 μL) 200 μL
CASP8-CFLAR-20-REAQ 20 (40 μL) 200 μL
CASP8-CFLAR-20-ORRE 20 (40 μL) 200 μL
CASP8-CFLAR-20-OROR 20 (40 μL) 200 μL
CASP8-CFLAR-20-ORGO 20 (40 μL) 200 μL
CASP8-CFLAR-20-ORAQ 20 (40 μL) 200 μL
CASP8-CFLAR-20-GORE 20 (40 μL) 200 μL
CASP8-CFLAR-20-GOOR 20 (40 μL) 200 μL
CASP8-CFLAR-20-GOGO 20 (40 μL) 200 μL
CASP8-CFLAR-20-GOGR 20 (40 μL) 200 μL
CASP8-CFLAR-20-GOAQ 20 (40 μL) 200 μL
CASP8-CFLAR-20-GRRE 20 (40 μL) 200 μL
CASP8-CFLAR-20-GROR 20 (40 μL) 200 μL
CASP8-CFLAR-20-GRGO 20 (40 μL) 200 μL
CASP8-CFLAR-20-GRGR 20 (40 μL) 200 μL
CASP8-CFLAR-20-GRAQ 20 (40 μL) 200 μL
CASP8-CFLAR-20-AQRE 20 (40 μL) 200 μL
CASP8-CFLAR-20-AQOR 20 (40 μL) 200 μL
CASP8-CFLAR-20-AQGO 20 (40 μL) 200 μL
CASP8-CFLAR-20-AQGR 20 (40 μL) 200 μL
CASP8-CFLAR-20-AQAQ 20 (40 μL) 200 μL

CASP8 Gene Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Gene Name: Caspase 8

Chromosome: CHR2: 202098165 -202152434

Locus: 2q33.1

CFLAR Gene Summary

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Gene Name: CASP8 And FADD Like Apoptosis Regulator

Chromosome: CHR2: 201980876 -202037411

Locus: 2q33.1

Gene Diseases

The CASP8 CFLAR Fusion has been associated with the following diseases:

Disease Name
Stomach Adenocarcinoma
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.