CAT-CD3D Fusion FISH Probe
The CAT-CD3D Fusion FISH Probe is used to confirm a fusion of the CAT and CD3D genes. The fusion of the CAT and CD3D genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAT-CD3D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-RERE | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-REOR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-REGO | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-REGR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-REAQ | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-ORRE | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-OROR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-ORGO | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GORE | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GOOR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GOGO | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GOGR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GRRE | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GROR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GRGO | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GRGR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-AQRE | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-AQOR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-AQGO | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-AQGR | 20 (40 μL) | 200 μL |
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| CAT-CD3D-20-AQAQ | 20 (40 μL) | 200 μL |
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CAT Gene Summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Gene Name: Catalase
Chromosome: CHR11: 34460471 -34493607
Locus: 11p13
CD3D Gene Summary
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
Gene Name: CD3d Molecule
Chromosome: CHR11: 118209788 -118213459
Locus: 11q23.3
Gene Diseases
The CAT CD3D Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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