CCND3-EXOC4 Fusion FISH Probe
The CCND3-EXOC4 Fusion FISH Probe is used to confirm a fusion of the CCND3 and EXOC4 genes. The fusion of the CCND3 and EXOC4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCND3-EXOC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-RERE | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-REOR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-REGO | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-REGR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-REAQ | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-ORRE | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-OROR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-ORGO | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GORE | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GOOR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GOGO | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GOGR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GRRE | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GROR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GRGO | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GRGR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-AQRE | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-AQOR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-AQGO | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-AQGR | 20 (40 μL) | 200 μL |
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| CCND3-EXOC4-20-AQAQ | 20 (40 μL) | 200 μL |
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CCND3 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Cyclin D3
Chromosome: CHR6: 41902670 -42016610
Locus: 6p21.1
EXOC4 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 4
Chromosome: CHR7: 132937822 -133750513
Locus: 7q33
Gene Diseases
The CCND3 EXOC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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