CCNL2-TYK2 Fusion FISH Probe
The CCNL2-TYK2 Fusion FISH Probe is used to confirm a fusion of the CCNL2 and TYK2 genes. The fusion of the CCNL2 and TYK2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CCNL2-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| CCNL2-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
CCNL2 Gene Summary
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Cyclin L2
Chromosome: CHR1: 1321090 -1334718
Locus: 1p36.33
Gene Diseases
The CCNL2 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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