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CD2AP-FKBP5 Fusion FISH Probe

The CD2AP-FKBP5 Fusion FISH Probe is used to confirm a fusion of the CD2AP and FKBP5 genes. The fusion of the CD2AP and FKBP5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CD2AP-FKBP5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CD2AP-FKBP5-20-RERE 20 (40 μL) 200 μL
CD2AP-FKBP5-20-REOR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-REGO 20 (40 μL) 200 μL
CD2AP-FKBP5-20-REGR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-REAQ 20 (40 μL) 200 μL
CD2AP-FKBP5-20-ORRE 20 (40 μL) 200 μL
CD2AP-FKBP5-20-OROR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-ORGO 20 (40 μL) 200 μL
CD2AP-FKBP5-20-ORAQ 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GORE 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GOOR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GOGO 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GOGR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GOAQ 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GRRE 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GROR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GRGO 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GRGR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-GRAQ 20 (40 μL) 200 μL
CD2AP-FKBP5-20-AQRE 20 (40 μL) 200 μL
CD2AP-FKBP5-20-AQOR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-AQGO 20 (40 μL) 200 μL
CD2AP-FKBP5-20-AQGR 20 (40 μL) 200 μL
CD2AP-FKBP5-20-AQAQ 20 (40 μL) 200 μL

FKBP5 Gene Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Gene Name: FK506 Binding Protein 5

Chromosome: CHR6: 35541361 -35696360

Locus: 6p21.31

CD2AP Gene Summary

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]

Gene Name: CD2 Associated Protein

Chromosome: CHR6: 47445524 -47594996

Locus: 6p12.3

Gene Diseases

The CD2AP FKBP5 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.