CD74-CXCR5 Fusion FISH Probe
The CD74-CXCR5 Fusion FISH Probe is used to confirm a fusion of the CD74 and CXCR5 genes. The fusion of the CD74 and CXCR5 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD74-CXCR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-RERE | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-REOR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-REGO | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-REGR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-REAQ | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-ORRE | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-OROR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-ORGO | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GORE | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GOOR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GOGO | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GOGR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GRRE | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GROR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GRGO | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GRGR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-AQRE | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-AQOR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-AQGO | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-AQGR | 20 (40 μL) | 200 μL |
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| CD74-CXCR5-20-AQAQ | 20 (40 μL) | 200 μL |
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CXCR5 Gene Summary
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: C-X-C Motif Chemokine Receptor 5
Chromosome: CHR11: 118754474 -118766980
Locus: 11q23.3
CD74 Gene Summary
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: CD74 Molecule
Chromosome: CHR5: 149781199 -149792499
Locus: 5q33.1
Gene Diseases
The CD74 CXCR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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