CD74-DDX27 Fusion FISH Probe
The CD74-DDX27 Fusion FISH Probe is used to confirm a fusion of the CD74 and DDX27 genes. The fusion of the CD74 and DDX27 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD74-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| CD74-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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CD74 Gene Summary
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: CD74 Molecule
Chromosome: CHR5: 149781199 -149792499
Locus: 5q33.1
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The CD74 DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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