CD83-LAMA2 Fusion FISH Probe
The CD83-LAMA2 Fusion FISH Probe is used to confirm a fusion of the CD83 and LAMA2 genes. The fusion of the CD83 and LAMA2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CD83-LAMA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-RERE | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-REOR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-REGO | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-REGR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-REAQ | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-ORRE | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-OROR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-ORGO | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GORE | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GOOR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GOGO | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GOGR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GRRE | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GROR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GRGO | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GRGR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-AQRE | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-AQOR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-AQGO | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-AQGR | 20 (40 μL) | 200 μL |
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| CD83-LAMA2-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA2 Gene Summary
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Laminin Subunit Alpha 2
Chromosome: CHR6: 129204285 -129837710
Locus: 6q22.33
CD83 Gene Summary
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: CD83 Molecule
Chromosome: CHR6: 14117864 -14137148
Locus: 6p23
Gene Diseases
The CD83 LAMA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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