CDC14B-AUH Fusion FISH Probe
The CDC14B-AUH Fusion FISH Probe is used to confirm a fusion of the CDC14B and AUH genes. The fusion of the CDC14B and AUH genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDC14B-AUH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CDC14B-AUH-20-AQAQ | 20 (40 μL) | 200 μL |
|
AUH Gene Summary
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Gene Name: AU RNA Binding Methylglutaconyl-CoA Hydratase
Chromosome: CHR9: 93976096 -94124206
Locus: 9q22.31
CDC14B Gene Summary
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Cell Division Cycle 14B
Chromosome: CHR9: 99262394 -99382112
Locus: 9q22.32-q22.33
Gene Diseases
The CDC14B AUH Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|