CDC25A-PRKAR2A Fusion FISH Probe
The CDC25A-PRKAR2A Fusion FISH Probe is used to confirm a fusion of the CDC25A and PRKAR2A genes. The fusion of the CDC25A and PRKAR2A genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC25A-PRKAR2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-RERE | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-REOR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-REGO | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-REGR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-OROR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GORE | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GROR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC25A-PRKAR2A-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC25A Gene Summary
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Cell Division Cycle 25A
Chromosome: CHR3: 48198667 -48229801
Locus: 3p21.31
PRKAR2A Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase CAMP-dependent Type II Regulatory Subunit Alpha
Chromosome: CHR3: 48788092 -48885270
Locus: 3p21.31
Gene Diseases
The CDC25A PRKAR2A Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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