CDC42BPA-WWOX Fusion FISH Probe
The CDC42BPA-WWOX Fusion FISH Probe is used to confirm a fusion of the CDC42BPA and WWOX genes. The fusion of the CDC42BPA and WWOX genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDC42BPA-WWOX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-RERE | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-REOR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-REGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-REGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-REAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-ORRE | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-OROR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-ORGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GORE | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GOOR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GOGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GOGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GRRE | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GROR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GRGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GRGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-AQRE | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-AQOR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-AQGO | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-AQGR | 20 (40 μL) | 200 μL |
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| CDC42BPA-WWOX-20-AQAQ | 20 (40 μL) | 200 μL |
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CDC42BPA Gene Summary
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
Gene Name: CDC42 Binding Protein Kinase Alpha
Chromosome: CHR1: 227177565 -227505826
Locus: 1q42.13
WWOX Gene Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: WW Domain Containing Oxidoreductase
Chromosome: CHR16: 78133326 -79246564
Locus: 16q23.1-q23.2
Gene Diseases
The CDC42BPA WWOX Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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