CDH12-BNIP3L Fusion FISH Probe
The CDH12-BNIP3L Fusion FISH Probe is used to confirm a fusion of the CDH12 and BNIP3L genes. The fusion of the CDH12 and BNIP3L genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDH12-BNIP3L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-RERE | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-REOR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-REGO | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-REGR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-REAQ | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-ORRE | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-OROR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-ORGO | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GORE | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GOOR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GOGO | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GOGR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GRRE | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GROR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GRGO | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GRGR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-AQRE | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-AQOR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-AQGO | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-AQGR | 20 (40 μL) | 200 μL |
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| CDH12-BNIP3L-20-AQAQ | 20 (40 μL) | 200 μL |
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BNIP3L Gene Summary
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Gene Name: BCL2 Interacting Protein 3 Like
Chromosome: CHR8: 26240522 -26270644
Locus: 8p21.2
CDH12 Gene Summary
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 12
Chromosome: CHR5: 21750972 -22853731
Locus: 5p14.3
Gene Diseases
The CDH12 BNIP3L Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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