CDH23-NSD1 Fusion FISH Probe
The CDH23-NSD1 Fusion FISH Probe is used to confirm a fusion of the CDH23 and NSD1 genes. The fusion of the CDH23 and NSD1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDH23-NSD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-RERE | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-REOR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-REGO | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-REGR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-REAQ | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-ORRE | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-OROR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-ORGO | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GORE | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GOOR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GOGO | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GOGR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GRRE | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GROR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GRGO | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GRGR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-AQRE | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-AQOR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-AQGO | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-AQGR | 20 (40 μL) | 200 μL |
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| CDH23-NSD1-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH23 Gene Summary
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]
Gene Name: Cadherin Related 23
Chromosome: CHR10: 73156690 -73575704
Locus: 10q22.1
NSD1 Gene Summary
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Binding SET Domain Protein 1
Chromosome: CHR5: 176560079 -176727214
Locus: 5q35.3
Gene Diseases
The CDH23 NSD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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