CDH8-RFX1 Fusion FISH Probe
The CDH8-RFX1 Fusion FISH Probe is used to confirm a fusion of the CDH8 and RFX1 genes. The fusion of the CDH8 and RFX1 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDH8-RFX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-RERE | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-REOR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-REGO | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-REGR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-REAQ | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-ORRE | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-OROR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-ORGO | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GORE | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GOOR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GOGO | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GOGR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GRRE | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GROR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GRGO | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GRGR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-AQRE | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-AQOR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-AQGO | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-AQGR | 20 (40 μL) | 200 μL |
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| CDH8-RFX1-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH8 Gene Summary
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
Gene Name: Cadherin 8
Chromosome: CHR16: 61685914 -62070739
Locus: 16q21
RFX1 Gene Summary
This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]
Gene Name: Regulatory Factor X1
Chromosome: CHR19: 14072341 -14117134
Locus: 19p13.12
Gene Diseases
The CDH8 RFX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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