CDK12-FBXL20 Fusion FISH Probe
The CDK12-FBXL20 Fusion FISH Probe is used to confirm a fusion of the CDK12 and FBXL20 genes. The fusion of the CDK12 and FBXL20 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK12-FBXL20-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-RERE | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-REOR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-REGO | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-REGR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-OROR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GORE | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GROR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK12-FBXL20-20-AQAQ | 20 (40 μL) | 200 μL |
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CDK12 Gene Summary
The Cyclin Dependent Kinase 12 (CDK12) gene is located on chr17 :37617738-37690800 at 17q12.
Gene Name: Cyclin Dependent Kinase 12
Chromosome: CHR17: 37617738 -37690800
Locus: 17q12
FBXL20 Gene Summary
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box And Leucine Rich Repeat Protein 20
Chromosome: CHR17: 37408896 -37557909
Locus: 17q12
Gene Diseases
The CDK12 FBXL20 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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