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CDK12-IKZF3 Fusion FISH Probe

The CDK12-IKZF3 Fusion FISH Probe is used to confirm a fusion of the CDK12 and IKZF3 genes. The fusion of the CDK12 and IKZF3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CDK12-IKZF3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CDK12-IKZF3-20-RERE 20 (40 μL) 200 μL
CDK12-IKZF3-20-REOR 20 (40 μL) 200 μL
CDK12-IKZF3-20-REGO 20 (40 μL) 200 μL
CDK12-IKZF3-20-REGR 20 (40 μL) 200 μL
CDK12-IKZF3-20-REAQ 20 (40 μL) 200 μL
CDK12-IKZF3-20-ORRE 20 (40 μL) 200 μL
CDK12-IKZF3-20-OROR 20 (40 μL) 200 μL
CDK12-IKZF3-20-ORGO 20 (40 μL) 200 μL
CDK12-IKZF3-20-ORAQ 20 (40 μL) 200 μL
CDK12-IKZF3-20-GORE 20 (40 μL) 200 μL
CDK12-IKZF3-20-GOOR 20 (40 μL) 200 μL
CDK12-IKZF3-20-GOGO 20 (40 μL) 200 μL
CDK12-IKZF3-20-GOGR 20 (40 μL) 200 μL
CDK12-IKZF3-20-GOAQ 20 (40 μL) 200 μL
CDK12-IKZF3-20-GRRE 20 (40 μL) 200 μL
CDK12-IKZF3-20-GROR 20 (40 μL) 200 μL
CDK12-IKZF3-20-GRGO 20 (40 μL) 200 μL
CDK12-IKZF3-20-GRGR 20 (40 μL) 200 μL
CDK12-IKZF3-20-GRAQ 20 (40 μL) 200 μL
CDK12-IKZF3-20-AQRE 20 (40 μL) 200 μL
CDK12-IKZF3-20-AQOR 20 (40 μL) 200 μL
CDK12-IKZF3-20-AQGO 20 (40 μL) 200 μL
CDK12-IKZF3-20-AQGR 20 (40 μL) 200 μL
CDK12-IKZF3-20-AQAQ 20 (40 μL) 200 μL

IKZF3 Gene Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

Gene Name: IKAROS Family Zinc Finger 3

Chromosome: CHR17: 37921198 -38020441

Locus: 17q12-q21.1

CDK12 Gene Summary

The Cyclin Dependent Kinase 12 (CDK12) gene is located on chr17 :37617738-37690800 at 17q12.

Gene Name: Cyclin Dependent Kinase 12

Chromosome: CHR17: 37617738 -37690800

Locus: 17q12

Gene Diseases

The CDK12 IKZF3 Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.