CDK5RAP3-RNF43 Fusion FISH Probe
The CDK5RAP3-RNF43 Fusion FISH Probe is used to confirm a fusion of the CDK5RAP3 and RNF43 genes. The fusion of the CDK5RAP3 and RNF43 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CDK5RAP3-RNF43-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-RERE | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-REOR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-REGO | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-REGR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-REAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-ORRE | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-OROR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-ORGO | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-ORAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GORE | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GOOR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GOGO | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GOGR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GOAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GRRE | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GROR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GRGO | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GRGR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-GRAQ | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-AQRE | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-AQOR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-AQGO | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-AQGR | 20 (40 μL) | 200 μL |
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| CDK5RAP3-RNF43-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF43 Gene Summary
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Name: Ring Finger Protein 43
Chromosome: CHR17: 56431037 -56494931
Locus: 17q22
CDK5RAP3 Gene Summary
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
Gene Name: CDK5 Regulatory Subunit Associated Protein 3
Chromosome: CHR17: 46048428 -46059147
Locus: 17q21.32
Gene Diseases
The CDK5RAP3 RNF43 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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