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CDKN2A-SOBP Fusion FISH Probe

The CDKN2A-SOBP Fusion FISH Probe is used to confirm a fusion of the CDKN2A and SOBP genes. The fusion of the CDKN2A and SOBP genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CDKN2A-SOBP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CDKN2A-SOBP-20-RERE 20 (40 μL) 200 μL
CDKN2A-SOBP-20-REOR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-REGO 20 (40 μL) 200 μL
CDKN2A-SOBP-20-REGR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-REAQ 20 (40 μL) 200 μL
CDKN2A-SOBP-20-ORRE 20 (40 μL) 200 μL
CDKN2A-SOBP-20-OROR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-ORGO 20 (40 μL) 200 μL
CDKN2A-SOBP-20-ORAQ 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GORE 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GOOR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GOGO 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GOGR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GOAQ 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GRRE 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GROR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GRGO 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GRGR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-GRAQ 20 (40 μL) 200 μL
CDKN2A-SOBP-20-AQRE 20 (40 μL) 200 μL
CDKN2A-SOBP-20-AQOR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-AQGO 20 (40 μL) 200 μL
CDKN2A-SOBP-20-AQGR 20 (40 μL) 200 μL
CDKN2A-SOBP-20-AQAQ 20 (40 μL) 200 μL

CDKN2A Gene Summary

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Gene Name: Cyclin Dependent Kinase Inhibitor 2A

Chromosome: CHR9: 21967750 -21994490

Locus: 9p21.3

SOBP Gene Summary

The protein encoded by this gene is a nuclear zinc finger protein that is involved in development of the cochlea. Defects in this gene have also been linked to intellectual disability. [provided by RefSeq, Mar 2011]

Gene Name: Sine Oculis Binding Protein Homolog

Chromosome: CHR6: 107811316 -107982513

Locus: 6q21

Gene Diseases

The CDKN2A SOBP Fusion has been associated with the following diseases:

Disease Name
Stomach Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.