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CELF1-MTCH2 Fusion FISH Probe

The CELF1-MTCH2 Fusion FISH Probe is used to confirm a fusion of the CELF1 and MTCH2 genes. The fusion of the CELF1 and MTCH2 genes has been associated with Lung Squamous Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CELF1-MTCH2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CELF1-MTCH2-20-RERE 20 (40 μL) 200 μL
CELF1-MTCH2-20-REOR 20 (40 μL) 200 μL
CELF1-MTCH2-20-REGO 20 (40 μL) 200 μL
CELF1-MTCH2-20-REGR 20 (40 μL) 200 μL
CELF1-MTCH2-20-REAQ 20 (40 μL) 200 μL
CELF1-MTCH2-20-ORRE 20 (40 μL) 200 μL
CELF1-MTCH2-20-OROR 20 (40 μL) 200 μL
CELF1-MTCH2-20-ORGO 20 (40 μL) 200 μL
CELF1-MTCH2-20-ORAQ 20 (40 μL) 200 μL
CELF1-MTCH2-20-GORE 20 (40 μL) 200 μL
CELF1-MTCH2-20-GOOR 20 (40 μL) 200 μL
CELF1-MTCH2-20-GOGO 20 (40 μL) 200 μL
CELF1-MTCH2-20-GOGR 20 (40 μL) 200 μL
CELF1-MTCH2-20-GOAQ 20 (40 μL) 200 μL
CELF1-MTCH2-20-GRRE 20 (40 μL) 200 μL
CELF1-MTCH2-20-GROR 20 (40 μL) 200 μL
CELF1-MTCH2-20-GRGO 20 (40 μL) 200 μL
CELF1-MTCH2-20-GRGR 20 (40 μL) 200 μL
CELF1-MTCH2-20-GRAQ 20 (40 μL) 200 μL
CELF1-MTCH2-20-AQRE 20 (40 μL) 200 μL
CELF1-MTCH2-20-AQOR 20 (40 μL) 200 μL
CELF1-MTCH2-20-AQGO 20 (40 μL) 200 μL
CELF1-MTCH2-20-AQGR 20 (40 μL) 200 μL
CELF1-MTCH2-20-AQAQ 20 (40 μL) 200 μL

CELF1 Gene Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Name: CUGBP Elav-like Family Member 1

Chromosome: CHR11: 47487488 -47574792

Locus: 11p11.2

MTCH2 Gene Summary

This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

Gene Name: Mitochondrial Carrier 2

Chromosome: CHR11: 47638857 -47664206

Locus: 11p11.2

Gene Diseases

The CELF1 MTCH2 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.