CFB-CCT5 Fusion FISH Probe
The CFB-CCT5 Fusion FISH Probe is used to confirm a fusion of the CFB and CCT5 genes. The fusion of the CFB and CCT5 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CFB-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CFB-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
|
CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The CFB CCT5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|