CHD3-RAD51C Fusion FISH Probe
The CHD3-RAD51C Fusion FISH Probe is used to confirm a fusion of the CHD3 and RAD51C genes. The fusion of the CHD3 and RAD51C genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHD3-RAD51C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CHD3-RAD51C-20-AQAQ | 20 (40 μL) | 200 μL |
|
CHD3 Gene Summary
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Chromodomain Helicase DNA Binding Protein 3
Chromosome: CHR17: 7788122 -7816075
Locus: 17p13.1
RAD51C Gene Summary
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: RAD51 Paralog C
Chromosome: CHR17: 56769962 -56811692
Locus: 17q22
Gene Diseases
The CHD3 RAD51C Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|