CHD6-CHRNB4 Fusion FISH Probe
The CHD6-CHRNB4 Fusion FISH Probe is used to confirm a fusion of the CHD6 and CHRNB4 genes. The fusion of the CHD6 and CHRNB4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHD6-CHRNB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-RERE | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-REOR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-REGO | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-REGR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-REAQ | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-ORRE | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-OROR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-ORGO | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GORE | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GOOR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GOGO | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GOGR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GRRE | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GROR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GRGO | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GRGR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-AQRE | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-AQOR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-AQGO | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-AQGR | 20 (40 μL) | 200 μL |
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| CHD6-CHRNB4-20-AQAQ | 20 (40 μL) | 200 μL |
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CHRNB4 Gene Summary
This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Gene Name: Cholinergic Receptor Nicotinic Beta 4 Subunit
Chromosome: CHR15: 78916635 -78933587
Locus: 15q25.1
CHD6 Gene Summary
This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]
Gene Name: Chromodomain Helicase DNA Binding Protein 6
Chromosome: CHR20: 40031169 -40247133
Locus: 20q12
Gene Diseases
The CHD6 CHRNB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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