CHD8-TG Fusion FISH Probe
The CHD8-TG Fusion FISH Probe is used to confirm a fusion of the CHD8 and TG genes. The fusion of the CHD8 and TG genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHD8-TG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-RERE | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-REOR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-REGO | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-REGR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-REAQ | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-ORRE | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-OROR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-ORGO | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GORE | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GOOR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GOGO | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GOGR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GRRE | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GROR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GRGO | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GRGR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-AQRE | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-AQOR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-AQGO | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-AQGR | 20 (40 μL) | 200 μL |
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| CHD8-TG-20-AQAQ | 20 (40 μL) | 200 μL |
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TG Gene Summary
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Gene Name: Thyroglobulin
Chromosome: CHR8: 133879204 -134147143
Locus: 8q24.22
CHD8 Gene Summary
This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
Gene Name: Chromodomain Helicase DNA Binding Protein 8
Chromosome: CHR14: 21853352 -21905457
Locus: 14q11.2
Gene Diseases
The CHD8 TG Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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