CHKA-CCNB3 Fusion FISH Probe
The CHKA-CCNB3 Fusion FISH Probe is used to confirm a fusion of the CHKA and CCNB3 genes. The fusion of the CHKA and CCNB3 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CHKA-CCNB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-RERE | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-REOR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-REGO | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-REGR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-REAQ | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-ORRE | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-OROR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-ORGO | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GORE | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GOOR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GOGO | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GOGR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GRRE | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GROR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GRGO | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GRGR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-AQRE | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-AQOR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-AQGO | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-AQGR | 20 (40 μL) | 200 μL |
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| CHKA-CCNB3-20-AQAQ | 20 (40 μL) | 200 μL |
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CHKA Gene Summary
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Choline Kinase Alpha
Chromosome: CHR11: 67820325 -67888858
Locus: 11q13.2
CCNB3 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Cyclin B3
Chromosome: CHRX: 50027539 -50094911
Locus: Xp11.22
Gene Diseases
The CHKA CCNB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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