CNTN5-ME3 Fusion FISH Probe
The CNTN5-ME3 Fusion FISH Probe is used to confirm a fusion of the CNTN5 and ME3 genes. The fusion of the CNTN5 and ME3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CNTN5-ME3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-RERE | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-REOR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-REGO | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-REGR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-REAQ | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-ORRE | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-OROR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-ORGO | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GORE | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GOOR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GOGO | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GOGR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GRRE | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GROR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GRGO | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GRGR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-AQRE | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-AQOR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-AQGO | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-AQGR | 20 (40 μL) | 200 μL |
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| CNTN5-ME3-20-AQAQ | 20 (40 μL) | 200 μL |
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ME3 Gene Summary
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Malic Enzyme 3
Chromosome: CHR11: 86152149 -86383678
Locus: 11q14.2
CNTN5 Gene Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Contactin 5
Chromosome: CHR11: 98891705 -100229616
Locus: 11q22.1
Gene Diseases
The CNTN5 ME3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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