COL18A1-HSPA5 Fusion FISH Probe
The COL18A1-HSPA5 Fusion FISH Probe is used to confirm a fusion of the COL18A1 and HSPA5 genes. The fusion of the COL18A1 and HSPA5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL18A1-HSPA5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-RERE | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-REOR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-REGO | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-REGR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-REAQ | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-ORRE | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-OROR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-ORGO | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GORE | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GOOR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GOGO | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GOGR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GRRE | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GROR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GRGO | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GRGR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-AQRE | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-AQOR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-AQGO | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-AQGR | 20 (40 μL) | 200 μL |
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| COL18A1-HSPA5-20-AQAQ | 20 (40 μL) | 200 μL |
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HSPA5 Gene Summary
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
Gene Name: Heat Shock Protein Family A (Hsp70) Member 5
Chromosome: CHR9: 127997126 -128003666
Locus: 9q33.3
COL18A1 Gene Summary
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Collagen Type XVIII Alpha 1 Chain
Chromosome: CHR21: 46825096 -46933634
Locus: 21q22.3
Gene Diseases
The COL18A1 HSPA5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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