COL22A1-RAD54B Fusion FISH Probe
The COL22A1-RAD54B Fusion FISH Probe is used to confirm a fusion of the COL22A1 and RAD54B genes. The fusion of the COL22A1 and RAD54B genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL22A1-RAD54B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-RERE | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-REOR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-REGO | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-REGR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-REAQ | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-ORRE | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-OROR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-ORGO | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GORE | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GOOR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GOGO | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GOGR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GRRE | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GROR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GRGO | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GRGR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-AQRE | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-AQOR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-AQGO | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-AQGR | 20 (40 μL) | 200 μL |
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| COL22A1-RAD54B-20-AQAQ | 20 (40 μL) | 200 μL |
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RAD54B Gene Summary
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: RAD54 Homolog B (S. Cerevisiae)
Chromosome: CHR8: 95384187 -95487343
Locus: 8q22.1
COL22A1 Gene Summary
This gene encodes member of the collagen family which is thought to contribute to the stabilization of myotendinous junctions and strengthen skeletal muscle attachments during contractile activity. It belongs to the fibril-associated collagens with interrupted triple helix (FACIT) subset of the collagen superfamily, which associate with collagen fibers through their C-terminal collagenous domains and mediate protein-protein interactions through their N-terminal noncollagenous domains. The encoded protein is deposited in the basement membrane zone of the myotendinous junction which is present only at the tissue junctions of muscles, tendons, the heart, articular cartilage, and skin. A knockdown of the orthologous zebrafish gene induces a muscular dystrophy by disruption of the myotendinous junction. [provided by RefSeq, May 2017]
Gene Name: Collagen Type XXII Alpha 1 Chain
Chromosome: CHR8: 139600477 -139926236
Locus: 8q24.23-q24.3
Gene Diseases
The COL22A1 RAD54B Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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