CPN1-ACTR1A Fusion FISH Probe
The CPN1-ACTR1A Fusion FISH Probe is used to confirm a fusion of the CPN1 and ACTR1A genes. The fusion of the CPN1 and ACTR1A genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPN1-ACTR1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-RERE | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-REOR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-REGO | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-REGR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-REAQ | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-ORRE | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-OROR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-ORGO | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GORE | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GOOR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GOGO | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GOGR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GRRE | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GROR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GRGO | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GRGR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-AQRE | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-AQOR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-AQGO | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-AQGR | 20 (40 μL) | 200 μL |
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| CPN1-ACTR1A-20-AQAQ | 20 (40 μL) | 200 μL |
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CPN1 Gene Summary
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
Gene Name: Carboxypeptidase N Subunit 1
Chromosome: CHR10: 101802064 -101841642
Locus: 10q24.2
ACTR1A Gene Summary
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Gene Name: ARP1 Actin Related Protein 1 Homolog A
Chromosome: CHR10: 104238985 -104262512
Locus: 10q24.32
Gene Diseases
The CPN1 ACTR1A Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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