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CREBBP-IFT140 Fusion FISH Probe

The CREBBP-IFT140 Fusion FISH Probe is used to confirm a fusion of the CREBBP and IFT140 genes. The fusion of the CREBBP and IFT140 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CREBBP-IFT140-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CREBBP-IFT140-20-RERE 20 (40 μL) 200 μL
CREBBP-IFT140-20-REOR 20 (40 μL) 200 μL
CREBBP-IFT140-20-REGO 20 (40 μL) 200 μL
CREBBP-IFT140-20-REGR 20 (40 μL) 200 μL
CREBBP-IFT140-20-REAQ 20 (40 μL) 200 μL
CREBBP-IFT140-20-ORRE 20 (40 μL) 200 μL
CREBBP-IFT140-20-OROR 20 (40 μL) 200 μL
CREBBP-IFT140-20-ORGO 20 (40 μL) 200 μL
CREBBP-IFT140-20-ORAQ 20 (40 μL) 200 μL
CREBBP-IFT140-20-GORE 20 (40 μL) 200 μL
CREBBP-IFT140-20-GOOR 20 (40 μL) 200 μL
CREBBP-IFT140-20-GOGO 20 (40 μL) 200 μL
CREBBP-IFT140-20-GOGR 20 (40 μL) 200 μL
CREBBP-IFT140-20-GOAQ 20 (40 μL) 200 μL
CREBBP-IFT140-20-GRRE 20 (40 μL) 200 μL
CREBBP-IFT140-20-GROR 20 (40 μL) 200 μL
CREBBP-IFT140-20-GRGO 20 (40 μL) 200 μL
CREBBP-IFT140-20-GRGR 20 (40 μL) 200 μL
CREBBP-IFT140-20-GRAQ 20 (40 μL) 200 μL
CREBBP-IFT140-20-AQRE 20 (40 μL) 200 μL
CREBBP-IFT140-20-AQOR 20 (40 μL) 200 μL
CREBBP-IFT140-20-AQGO 20 (40 μL) 200 μL
CREBBP-IFT140-20-AQGR 20 (40 μL) 200 μL
CREBBP-IFT140-20-AQAQ 20 (40 μL) 200 μL

CREBBP Gene Summary

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

Gene Name: CREB Binding Protein

Chromosome: CHR16: 3775055 -3930121

Locus: 16p13.3

IFT140 Gene Summary

This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]

Gene Name: Intraflagellar Transport 140

Chromosome: CHR16: 1560427 -1662109

Locus: 16p13.3

Gene Diseases

The CREBBP IFT140 Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.