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CRIM1-HAAO Fusion FISH Probe

The CRIM1-HAAO Fusion FISH Probe is used to confirm a fusion of the CRIM1 and HAAO genes. The fusion of the CRIM1 and HAAO genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CRIM1-HAAO-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CRIM1-HAAO-20-RERE 20 (40 μL) 200 μL
CRIM1-HAAO-20-REOR 20 (40 μL) 200 μL
CRIM1-HAAO-20-REGO 20 (40 μL) 200 μL
CRIM1-HAAO-20-REGR 20 (40 μL) 200 μL
CRIM1-HAAO-20-REAQ 20 (40 μL) 200 μL
CRIM1-HAAO-20-ORRE 20 (40 μL) 200 μL
CRIM1-HAAO-20-OROR 20 (40 μL) 200 μL
CRIM1-HAAO-20-ORGO 20 (40 μL) 200 μL
CRIM1-HAAO-20-ORAQ 20 (40 μL) 200 μL
CRIM1-HAAO-20-GORE 20 (40 μL) 200 μL
CRIM1-HAAO-20-GOOR 20 (40 μL) 200 μL
CRIM1-HAAO-20-GOGO 20 (40 μL) 200 μL
CRIM1-HAAO-20-GOGR 20 (40 μL) 200 μL
CRIM1-HAAO-20-GOAQ 20 (40 μL) 200 μL
CRIM1-HAAO-20-GRRE 20 (40 μL) 200 μL
CRIM1-HAAO-20-GROR 20 (40 μL) 200 μL
CRIM1-HAAO-20-GRGO 20 (40 μL) 200 μL
CRIM1-HAAO-20-GRGR 20 (40 μL) 200 μL
CRIM1-HAAO-20-GRAQ 20 (40 μL) 200 μL
CRIM1-HAAO-20-AQRE 20 (40 μL) 200 μL
CRIM1-HAAO-20-AQOR 20 (40 μL) 200 μL
CRIM1-HAAO-20-AQGO 20 (40 μL) 200 μL
CRIM1-HAAO-20-AQGR 20 (40 μL) 200 μL
CRIM1-HAAO-20-AQAQ 20 (40 μL) 200 μL

HAAO Gene Summary

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]

Gene Name: 3-hydroxyanthranilate 3,4-dioxygenase

Chromosome: CHR2: 42994228 -43019751

Locus: 2p21

CRIM1 Gene Summary

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

Gene Name: Cysteine Rich Transmembrane BMP Regulator 1

Chromosome: CHR2: 36583369 -36778278

Locus: 2p22.2

Gene Diseases

The CRIM1 HAAO Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Papillary Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.