CRK-STX8 Fusion FISH Probe
The CRK-STX8 Fusion FISH Probe is used to confirm a fusion of the CRK and STX8 genes. The fusion of the CRK and STX8 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRK-STX8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-RERE | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-REOR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-REGO | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-REGR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-REAQ | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-ORRE | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-OROR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-ORGO | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GORE | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GOOR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GOGO | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GOGR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GRRE | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GROR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GRGO | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GRGR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-AQRE | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-AQOR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-AQGO | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-AQGR | 20 (40 μL) | 200 μL |
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| CRK-STX8-20-AQAQ | 20 (40 μL) | 200 μL |
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CRK Gene Summary
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Gene Name: CRK Proto-oncogene, Adaptor Protein
Chromosome: CHR17: 1325457 -1359544
Locus: 17p13.3
STX8 Gene Summary
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Name: Syntaxin 8
Chromosome: CHR17: 9153787 -9479275
Locus: 17p13.1
Gene Diseases
The CRK STX8 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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