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CRLF3-CRHR1 Fusion FISH Probe

The CRLF3-CRHR1 Fusion FISH Probe is used to confirm a fusion of the CRLF3 and CRHR1 genes. The fusion of the CRLF3 and CRHR1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CRLF3-CRHR1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CRLF3-CRHR1-20-RERE 20 (40 μL) 200 μL
CRLF3-CRHR1-20-REOR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-REGO 20 (40 μL) 200 μL
CRLF3-CRHR1-20-REGR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-REAQ 20 (40 μL) 200 μL
CRLF3-CRHR1-20-ORRE 20 (40 μL) 200 μL
CRLF3-CRHR1-20-OROR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-ORGO 20 (40 μL) 200 μL
CRLF3-CRHR1-20-ORAQ 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GORE 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GOOR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GOGO 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GOGR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GOAQ 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GRRE 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GROR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GRGO 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GRGR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-GRAQ 20 (40 μL) 200 μL
CRLF3-CRHR1-20-AQRE 20 (40 μL) 200 μL
CRLF3-CRHR1-20-AQOR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-AQGO 20 (40 μL) 200 μL
CRLF3-CRHR1-20-AQGR 20 (40 μL) 200 μL
CRLF3-CRHR1-20-AQAQ 20 (40 μL) 200 μL

CRHR1 Gene Summary

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]

Gene Name: Corticotropin Releasing Hormone Receptor 1

Chromosome: CHR17_ctg5_hap1: 954314 -1170453

Locus: 17q21.31

CRLF3 Gene Summary

This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

Gene Name: Cytokine Receptor Like Factor 3

Chromosome: CHR17: 29109701 -29151778

Locus: 17q11.2

Gene Diseases

The CRLF3 CRHR1 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.