CST3-CCT5 Fusion FISH Probe
The CST3-CCT5 Fusion FISH Probe is used to confirm a fusion of the CST3 and CCT5 genes. The fusion of the CST3 and CCT5 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CST3-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| CST3-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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CST3 Gene Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]
Gene Name: Cystatin C
Chromosome: CHR20: 23614293 -23618574
Locus: 20p11.21
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The CST3 CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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