CTCF-CES2 Fusion FISH Probe
The CTCF-CES2 Fusion FISH Probe is used to confirm a fusion of the CTCF and CES2 genes. The fusion of the CTCF and CES2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTCF-CES2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-RERE | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-REOR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-REGO | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-REGR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-REAQ | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-ORRE | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-OROR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-ORGO | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GORE | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GOOR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GOGO | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GOGR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GRRE | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GROR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GRGO | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GRGR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-AQRE | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-AQOR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-AQGO | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-AQGR | 20 (40 μL) | 200 μL |
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| CTCF-CES2-20-AQAQ | 20 (40 μL) | 200 μL |
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CES2 Gene Summary
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Gene Name: Carboxylesterase 2
Chromosome: CHR16: 66968346 -66978994
Locus: 16q22.1
CTCF Gene Summary
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Name: CCCTC-binding Factor
Chromosome: CHR16: 67596309 -67673088
Locus: 16q22.1
Gene Diseases
The CTCF CES2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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