CTCF-E2F4 Fusion FISH Probe
The CTCF-E2F4 Fusion FISH Probe is used to confirm a fusion of the CTCF and E2F4 genes. The fusion of the CTCF and E2F4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTCF-E2F4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-RERE | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-REOR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-REGO | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-REGR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-REAQ | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-ORRE | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-OROR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-ORGO | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GORE | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GOOR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GOGO | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GOGR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GRRE | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GROR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GRGO | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GRGR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-AQRE | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-AQOR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-AQGO | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-AQGR | 20 (40 μL) | 200 μL |
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| CTCF-E2F4-20-AQAQ | 20 (40 μL) | 200 μL |
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E2F4 Gene Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Gene Name: E2F Transcription Factor 4
Chromosome: CHR16: 67226067 -67232821
Locus: 16q22.1
CTCF Gene Summary
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Name: CCCTC-binding Factor
Chromosome: CHR16: 67596309 -67673088
Locus: 16q22.1
Gene Diseases
The CTCF E2F4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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